진단/치료용 나노의약품 개발 (Theranostic Nanomedicine)
생체적합성 고분자개발 (Biocompatible polymers for biomedical applications)
암 치료용 나노입자 개발 (Polymeric micelles for tumor targeting)
조직공학용 주입형 나노젤 개발 (Injectable nanogels for tissue engineering)
양이온 고분자를 이용한 유전자 전달체 개발 (Cationic polymers for gene delivery)
분자영상용 나노프로브개발 (Polymeric nanoprobe for molecular imaging)
학력
(Ph.D.) 공학박사(GIST, 2002)
약력/경력
한국과학기술연구원 박사후연구원 (2002 - 2004)
Purdue University 박사후 연구원 (2004- 2005)
경희대학교 화학공학과 조교수/부교수 (2005-2011)
삼성융합의과학원 겸직교수 (2012-현재)
학술지 논문
(2024)
Mucoadhesive chitosan microcapsules for controlled gastrointestinal delivery and oral bioavailability enhancement of low molecular weight peptides.
JOURNAL OF CONTROLLED RELEASE.
365,
(2024)
Immunogenic extracellular vesicles derived from endoplasmic reticulum-stressed tumor cells: Implications as the therapeutic cancer vaccine.
ACS NANO.
18,
(2023)
Imaging of tumor‑associated macrophages using near‑infrared fuorophore‑conjugated dextran‑sulfate nanoparticles.
MACROMOLECULAR RESEARCH.
31,
(2023)
Disease-microenvironment modulation by bare- or engineered-exosome for rheumatoid arthritis treatment.
BIOMATERIALS RESEARCH.
27,
1
(2023)
Blending low-frequency vibrations and push–pull effects affords superior photoacoustic imaging agents.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.
62,
1
(2023)
Functionally Masked Antibody to Uncouple Immune-Related Toxicities in Checkpoint Blockade Cancer Therapy.
ACS NANO.
17,
11
(2023)
Role of high-temperature requirement serine protease A 2 in rheumatoid inflammation.
ARTHRITIS RESEARCH & THERAPY.
25,
1
(2023)
Cascade-amplified self-immolative polymeric prodrug for cancer therapy by disrupting redox homeostasis.
JOURNAL OF CONTROLLED RELEASE.
358,
(2023)
Curvature-sensing peptide inhibits tumour-derived exosomes for enhanced cancer immunotherapy.
NATURE MATERIALS.
22,
5
(2023)
Self-immolative polymer-based immunogenic cell death inducer for regulation of redox homeostasis.
BIOMATERIALS.
295,
-
(2023)
Plant-derived nanovesicles: Current understanding and applications for cancer therapy.
BIOACTIVE MATERIALS.
22,
(2022)
Hyaluronic Acid Nanoparticles as a Topical Agent for Treating Psoriasis.
ACS NANO.
16,
(2022)
Recent progress in nitric oxide-generating nanomedicine for cancer therapy.
JOURNAL OF CONTROLLED RELEASE.
352,
(2022)
Evading Doxorubicin-Induced Systemic Immunosuppression Using Ultrasound-Responsive Liposomes Combined with Focused Ultrasound.
PHARMACEUTICS.
14,
12
(2022)
Liposome-mediated PD-L1 multivalent binding promotes the lysosomal degradation of PD-L1 for T cell-mediated antitumor immunity.
BIOMATERIALS.
290,
(2022)
Self-Immolative Polymer-Based Chemiluminescent Nanoparticles for Long-Term In Vivo Imaging of Reactive Oxygen Species.
CHEMISTRY OF MATERIALS.
34,
17
(2022)
Functional Extracellular Vesicles for Regenerative Medicine.
SMALL.
18,
36
(2022)
Dissolving microneedles for long-term storage and transdermal delivery of extracellular vesicles.
BIOMATERIALS.
287,
1
(2022)
Regulation of in vivo fate of exosomes for therapeutic applications: New frontier in nanomedicines.
JOURNAL OF CONTROLLED RELEASE.
348,
특허/프로그램
히알루론산 나노입자를 함유하는 섬유증의 예방 또는 치료용 약학 조성물.
10-2018-0116838.
20201001.
대한민국
지방줄기세포유래 엑소좀을 유효성분으로 포함하는 간 섬유증 예방 또는 치료용 조성물.
10-2017-0154641.
20200918.
대한민국
다양한 세포로부터의 표면개질된 엑소좀의 제조방법(Method for producing surface-modified exosomes from various cells).
10-2063-5710000.
20200102.
대한민국
히알루론산을 포함하는 핵산전달용 조성물(Composition for nucleic acid delivery containing hyaluronic acid).
10-2049-5680000.
20191121.
대한민국
금 나노클러스터 함유 양친성 고분자 나노조립체 기반 광열 및 광역학 치료용 약물 전달체 및 이의 제조 방법(DRUG CARRIER FOR PHOTOTHERMAL AND PHOTODYNAMIC THERAPY BASED ON NANOASSEBLY COMPRISING GOLD NANOCLUSTER AND FABRICATION METHOD OF THE DRUG CARRIER).
10-1928-1610000.
20181205.
대한민국
혈관확장 유도형 기체발생 나노입자, 이의 제조방법 및 이를 포함하는 약물전달체.
10-2017-0062409.
20181011.
대한민국
히알루론산 나노입자를 함유하는 염증질환 및 대사질환의 예방 또는 치료용 약학 조성물(Pharmaceutical Composition for Preventing or Treating of Inflammatory Diseases and Metabolic Diseases Comprising hyaluronic acid Nanoparticles).
10-1905-8630000.
20181001.
대한민국
활성 산소종 관련 질환의 진단/치료용 디셀레나이드 가교결합을 함유한 블록 공중합체 및 이의 제조방법(Block copolymer containing diselenide-crosslinked for reactive oxygen species-related diagnosis/treatment and manufacturing method therof).
10-1818-3770000.
20180108.
대한민국
표면전하 전환형 약물전달용 나노입자 및 이의 제조방법(surface charge conversion type nanoparticles for drug delivery and manufacturing method thereof).
10-1797-8290000.
20171108.
대한민국
Method for nucleic acid delivery using hyaluronic acid.
14/242568.
20170829.
미국
당화합물(sugar chemical compound)-탁산화합물(taxane compound) 접합체를 포함하는 암의 예방 또는 치료용 약학적 조성물 및 이의 제조 방법(A pharmaceutical composition for preventing or treating cancer comprising sugar chemical compound-taxane compound conjugate and a method for preparation thereof).
10-1732-7960000.
20170426.
대한민국
금나노 입자를 함유하는 암세포 특이적 siRNA 전달체의 제조 방법(Method of producing a tumor specific siRNA delivery system containing gold nano particles).
10-1721-7520000.
20170324.
대한민국
산화티타늄 나노입자를 유효성분으로 함유하는 음파감작용 조성물, 이를 포함하는 암의 예방 또는 치료용 조성물 및 이의 제조방법(Sonosensitizer composition containing titanium oxide nanoparticle as active ingredient, composition for preventing or treating cancer comprising the same, and the preparation thereof).
10-1702-2270000.
20170125.
대한민국
Hypoxia-Responsive Nanoparticle for Therapy and Imaging of Hypoxia-Involving Diseases.
14/078,075.
20150721.
미국
히알루론산-메토트렉세이트 접합체를 포함하는 관절염 예방 또는 치료용 약학적 조성물 및 이의 제조방법.
10-2013-0018322.
20141124.
대한민국
저산소증 관련 질환의 진단 및 치료용 저산소 감응형 나노입자.
10-2013-0137195.
20141121.
대한민국
무기화된 폴리에틸렌 글리콜 함유 양친성 나노입자를 포함하는 약물 전달체.
10-2011-0141737.
20140109.
대한민국
덱스트란 설페이트를 포함하는 블록공중합체로 도포된 산화철 복합 나노입자, 이의 제조방법 및.
10-2011-0141744.
20130709.
대한민국
(2020)
Surface-engineered exosomes for targeted therapy of inflammatory diseases.
The 30th Frontier Scientists Workshop.
대한민국
(2020)
Stimuli-Responsive Polymeric Nanomedicine for Cancer Immunotherapy.
International Conference of The Korean Society of Pharmaceutical Science and Technology.
대한민국
(2020)
A dextran-based nitric oxide donor for enhanced delivery of anticancer therapeutics.
2020 KSIEC Annual Meeting.
대한민국
(2020)
A reinterpretation of chemiluminescence resonance energy transfer-based nanoparticles for enhancement of quantum yield in cancer phototheranostics.
2020 한국공업화학회 학술대회.
대한민국
(2020)
Effects of exosomal surface modification on in vivo biodistribution in mice with tumor and rhematoid arthritis.
2020 한국공업화학회 학술대회.
대한민국
(2020)
Immunogenic cell death-inducible nanobubbles for cancer immunotherapy.
2020 한국공업화학회 학술대회.
대한민국
(2020)
Surface engineering approaches to modulate in vivo fates of exosomes.
2020 Fall International Convention of The Pharmaceutical Society of Korea.
대한민국
(2020)
Development of pH-responsive polymeric nanocarrier for delivery of methotrexate to rheumatoid arthritis.
한국고분자학회 추계학술대회.
대한민국
(2020)
Enhancement of ROS Quantum Yield of Photosensitizer by Chemiluminescence Resonance Energy Transfer for Photodynamic Cancer Therapy.
한국고분자학회 추계학술대회.
대한민국
(2020)
Polymeric Sonosensitizer Nanoparticles for in situ Cancer Vaccination.
한국고분자학회 추계학술대회.
대한민국
(2020)
The pH-responsiveness of metal-phenolic network-coated polymeric nanoparticles for targeted cancer therapy.
한국고분자학회 추계학술대회.
대한민국
(2020)
Cancer nanomedicines to modulate in vivo fates of small extracellular vesicles.
The 22nd Frontier Scientist Workshop.
대한민국
(2019)
Stimuli-Responsive Polymer Nanomedicines for ROS-Mediated Cancer Therapy.
IEEE-NANOMED 2019.
대한민국
(2019)
A tumor microenvironment-recognizable polymeric conjugate for antigen delivery and cancer immunotherapy.
SITC 2019.
미국
(2019)
Targeted delivery system for toll-like receoptor agonists to repolarize the immunosuppressive phenotype of tumor-associated macrophages.
SITC 2019.
미국
(2019)
Image-guided sonodynamic therapy using perflurorohexane-bearing titania-coated mesoporous silica nanoparticles.
한국공업화학회 추계학술대회.
대한민국
(2019)
Self-illuminating nanoparticles for in vivo ROS imaging and photodynamic cancer therapy.
한국공업화학회 추계학술대회.
대한민국
(2019)
Stimuli-Responsive Polymer Nanomedicines for Reactive Oxygen Species-Mediated Approach to Treat Cancer.
FAPS 2019.
대만
(2019)
A Polymeric Conjugate to Modulate Immune Responses in Cancer.
한국고분자학회 추계학술대회.
대한민국
(2019)
Surface-Engineered Exosomes for Therapeutic Applications.
2019년 한국생체재료학회 추계 학술대회.
대한민국
